Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2013
Effect of herbal formula xiao pi-II on functional dyspepsia.
СтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Liu Baohai, Piao Xuehua, Guo Lianyi
Аннотация
OBJECTIVE: To investigate the therapeutic effect of the herbal medication Xiao Pi-II on the symptoms and gastric motility of patients with functional dysepsia (FD).
METHODS: A total of 180 FD patients were divided randomly and equally into Xiao Pi-II and mosapride groups. The two groups were treated with Xiao Pi-II (100 mL, t.d.s., ante cibum) and mosapride (5 mg, t. d.s., ante cibum) for 2 weeks. Before treatment and 3 days after all medication was stopped, patients responded to a questionnaire evaluating gastrointestinal symptoms and were assessed with abdominal three dimensional ultrasonography (3D-US) for gastric motility.
RESULTS: Gastrointestinal symptoms (especially bloating, post-prandial fullness and eructation) were improved significantly in FD patients treated with Xiao Pi-II (P < 0.05, P < 0.05, and P < 0.05), but no significant difference was found in the mosapride group (P > 0.05). The effective rates in the Xiao Pi-II and mosapride group were 86.7% and 60.0%, respectively (P < 0.05). The gastric liquid emptying rate (GLER) in the Xiao Pi-II group showed a significant increase (P < 0.01) after 2 weeks of treatment but there was no significant change (P > 0.05) of GLER in the mosapride group.
CONCLUSION: Compared with mosapride, Xiao Pi-II improved symptoms and GLER significantly in FD patients with delayed gastric emptying.
METHODS: A total of 180 FD patients were divided randomly and equally into Xiao Pi-II and mosapride groups. The two groups were treated with Xiao Pi-II (100 mL, t.d.s., ante cibum) and mosapride (5 mg, t. d.s., ante cibum) for 2 weeks. Before treatment and 3 days after all medication was stopped, patients responded to a questionnaire evaluating gastrointestinal symptoms and were assessed with abdominal three dimensional ultrasonography (3D-US) for gastric motility.
RESULTS: Gastrointestinal symptoms (especially bloating, post-prandial fullness and eructation) were improved significantly in FD patients treated with Xiao Pi-II (P < 0.05, P < 0.05, and P < 0.05), but no significant difference was found in the mosapride group (P > 0.05). The effective rates in the Xiao Pi-II and mosapride group were 86.7% and 60.0%, respectively (P < 0.05). The gastric liquid emptying rate (GLER) in the Xiao Pi-II group showed a significant increase (P < 0.01) after 2 weeks of treatment but there was no significant change (P > 0.05) of GLER in the mosapride group.
CONCLUSION: Compared with mosapride, Xiao Pi-II improved symptoms and GLER significantly in FD patients with delayed gastric emptying.