International journal of molecular sciences · 2025
Unraveling the Role of Autotaxin and Lysophosphatidic Acid in Alzheimer's Disease: From Molecular Mechanisms to Therapeutic Potential.
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García-de Soto Jesús, Castro-Mosquera Mónica, Pouso-Diz Jessica María, Fernández-Cabrera Alejandro, Rodríguez-Arrizabalaga Mariña, Debasa-Mouce Manuel, Camino-Castiñeiras Javier, Minguillón Pereiro Anxo Manuel, Aramburu-Núñez Marta, Romaus-Sanjurjo Daniel, Aldrey José Manuel, Pego-Reigosa Robustiano, Pías-Peleteiro Juan Manuel, Sobrino Tomás, Ouro Alberto
Аннотация
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-β plaques, tau hyperphosphorylation, and chronic neuroinflammation. Emerging evidence suggests a crucial role of lipid signaling pathways in AD pathogenesis, particularly those mediated by autotaxin (ATX) and lysophosphatidic acid (LPA). ATX, an enzyme responsible for LPA production, has been implicated in neuroinflammatory processes, blood-brain barrier dysfunction, and neuronal degeneration. LPA signaling, through its interaction with specific G-protein-coupled receptors, influences neuroinflammation, synaptic plasticity, and tau pathology, all of which contribute to AD progression. This review synthesizes recent findings on the ATX/LPA axis in AD, exploring its potential as a biomarker and therapeutic target. Understanding the mechanistic links between ATX, LPA, and AD pathology may open new avenues for disease-modifying strategies.