Parasitology international · 2018
Atypical virulence in a type III Toxoplasma gondii strain isolated in Japan.
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Taniguchi Yuji, Appiah-Kwarteng Cornelia, Murakami Mami, Fukumoto Junpei, Nagamune Kisaburo, Matsuo Tomohide, Masatani Tatsunori, Kanuka Hirotaka, Hoshina Tokio, Kitoh Katsuya, Takashima Yasuhiro
Аннотация
The virulence of a type III Toxoplasma gondii strain isolated in Japan and designated here as TgCatJpGi1/TaJ was examined in mice and micro minipigs in this study. Despite its type III genotype, oral or intraperitoneal inoculation of cysts from it resulted in severe virulence in C57BL/6J and BALB/c mice. In contrast, mice inoculated with a high dose of TgCatJpGi1/TaJ tachyzoites showed no obvious clinical signs of infection, and all of them survived for >21 days post-inoculation. Furthermore, no clinical signs of infection were seen when micro minipigs were inoculated with 900 cysts. Interestingly, our allelic type screening of the virulence-related rop5, rop16, rop17, and rop18 genes, as based on restriction fragment length polymorphism analysis (RFLP), revealed that the RFLP patterns for TgCatJpGi1/TaJ were identical to those from nonvirulent type III parasites. These results suggest that TgCatJpGi1/TaJ possesses an unknown virulence factor or factors.