[A Case of Unresectable Gallbladder Carcinoma Achieving Pathological Response after Neoadjuvant GCD Therapy Followed by Curative Resection].

The patient was a man in his 70s who presented with epigastric pain and was referred to our department with a suspected diagnosis of gallbladder cancer. He was diagnosed with gallbladder cancer and metastasis to the paraaortic lymph nodes, and underwent 8 courses of gemcitabine, cisplatin, durvalumab(GCD)therapy. Following a favorable tumor response, he underwent gallbladder bed resection, extrahepatic bile duct resection, and lymphadenectomy. Postoperative pathological examination confirmed the presence of intraepithelial carcinoma, with a therapeutic effect graded as Grade 4, indicating a pathological near-complete response(near-pCR). Postoperative immune-related adverse event(irAE)enteritis and hypothyroidism were noted, highlighting the importance of perioperative management of irAEs.