Age and ageing · 2025
Minimal clinically important difference and substantial clinical benefits for single- and dual-task timed up and go test following motor-cognitive training in Parkinson's disease.
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Taghizadeh Ghorban, Eissazade Negin, Fereshtehnejad Seyed-Mohammad, Taghavi Azar Sharabiani Parvaneh, Shati Mohsen, Mortazavi Seyede Salehe, Habibi Sayed Amir Hasan, SalemiJuybari Maryam, Mehdizadeh Maryam
Аннотация
OBJECTIVE: To establish substantial clinical benefits (SCB) and minimal clinically important differences (MCIDs) for both the single-task and dual-task timed up and go (TUG) tests in people with Parkinson's disease (PwPD).
DESIGN: Prospective pre-post intervention study evaluating the effects of combined motor-cognitive training.
SETTING: Rehabilitation centers.
PARTICIPANTS: One hundred fifteen PwPD, with a mean age of 61.33 ± 13.01 years.
INTERVENTIONS: Dual-task motor-cognitive training.
MAIN OUTCOME MEASURES: Time taken to complete the single-task and dual-task TUG tests, recorded both before and after the intervention. MCIDs were calculated using the anchor-based and distribution-based methods. SCB was assessed using the receiver operating characteristic (ROC) curve analysis.
RESULTS: The anchor-based MCIDs for the single-task and dual-task TUG tests ranged from -0.71 to -1.27, and - 0.82 to -1.81, respectively. The distribution-based MCIDs for the single-task and dual-task TUG tests ranged from -1.07 to -1.14, and - 1.65 to -1.98, respectively. The SCB for both the single-task and dual-task TUG tests was determined to be less than -2.04.
CONCLUSION: This investigation provides critical insights into interpreting changes in functional mobility in PwPD, facilitating informed clinical interventions and enhancing research planning initiatives.
DESIGN: Prospective pre-post intervention study evaluating the effects of combined motor-cognitive training.
SETTING: Rehabilitation centers.
PARTICIPANTS: One hundred fifteen PwPD, with a mean age of 61.33 ± 13.01 years.
INTERVENTIONS: Dual-task motor-cognitive training.
MAIN OUTCOME MEASURES: Time taken to complete the single-task and dual-task TUG tests, recorded both before and after the intervention. MCIDs were calculated using the anchor-based and distribution-based methods. SCB was assessed using the receiver operating characteristic (ROC) curve analysis.
RESULTS: The anchor-based MCIDs for the single-task and dual-task TUG tests ranged from -0.71 to -1.27, and - 0.82 to -1.81, respectively. The distribution-based MCIDs for the single-task and dual-task TUG tests ranged from -1.07 to -1.14, and - 1.65 to -1.98, respectively. The SCB for both the single-task and dual-task TUG tests was determined to be less than -2.04.
CONCLUSION: This investigation provides critical insights into interpreting changes in functional mobility in PwPD, facilitating informed clinical interventions and enhancing research planning initiatives.