[Endocrinology complications of Langerhans cell histiocytosis].

The aim of presentation is an unusual case report of a 17 year old boy with short statured (SD (-)4), absent puberty and thyroid enlargement. Endocrine tests demonstrated a growth hormone and gonadotropin deficiency with diabetes insipidus. Magnetic resonance imaging showed a small pituitary gland and an absence of the posterior bright signal. Fine needle aspiration cytology of the focus localized in the left lobe of thyroid gland and nearest enlarged lymph nodes revealed diffuse infiltrate by the large histiocytosis confirming Langerhans cell histiocytosis like in the skin histological specimen biopsy. After chemotherapy we observed a regretion of focal changes in the thyroid.