Biomarkers in medicine · 2026
Prognostic value of blood urea nitrogen-creatinine ratio for rehospitalization and outcomes in myocardial infarction: a four-year retrospective cohort analysis.
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Ebrahimi Atiyeh, Salari Arsalan, Gholami-Chaboki Bahare, Borghei Amirhossein, Mirrazeghi Seyedeh Fatemeh, Mousavi Seyed Mehdi, Borghei Yasaman
Аннотация
BACKGROUND: Risk stratification in acute myocardial infarction (AMI) remains a critical challenge in clinical practice. Traditional prognostic markers often require complex or costly assessments, underscoring the need for simple, accessible indicators. This study, conducted with the aim of evaluating the relationship between the blood urea nitrogen (BUN) and creatinine (Cr) ratio and rehospitalization following AMI.
METHODS: This retrospective cohort study, conducted at a single center, patients diagnosed with AMI. BUN and Cr levels at the time of initial admission were collected to calculate the BUN/Cr ratio, which was categorized into two groups: ≤16.23 and >16.23. Statistical analyses were carried out using IBM SPSS software (version 22).
RESULTS: Among 1147 AMI patients, 53% had BUN/Cr ≤16.23 and 42.1% >16.23. Over four years, rehospitalization rates were slightly higher in the high BUN/Cr group but not statistically significant (p > 0.05). Primary outcomes differed significantly, with mortality notably higher in patients with elevated BUN/Cr ratios (3.7% vs. 1.1%) (p < 0.05).
CONCLUSION: While rehospitalization rates over a four‑year period were slightly higher among those with elevated ratios, the difference was not statistically significant. However, patients with a BUN/Cr ratio >16.23 demonstrated markedly increased rates of major adverse cardiac events (MACE) compared to those with lower ratios.
METHODS: This retrospective cohort study, conducted at a single center, patients diagnosed with AMI. BUN and Cr levels at the time of initial admission were collected to calculate the BUN/Cr ratio, which was categorized into two groups: ≤16.23 and >16.23. Statistical analyses were carried out using IBM SPSS software (version 22).
RESULTS: Among 1147 AMI patients, 53% had BUN/Cr ≤16.23 and 42.1% >16.23. Over four years, rehospitalization rates were slightly higher in the high BUN/Cr group but not statistically significant (p > 0.05). Primary outcomes differed significantly, with mortality notably higher in patients with elevated BUN/Cr ratios (3.7% vs. 1.1%) (p < 0.05).
CONCLUSION: While rehospitalization rates over a four‑year period were slightly higher among those with elevated ratios, the difference was not statistically significant. However, patients with a BUN/Cr ratio >16.23 demonstrated markedly increased rates of major adverse cardiac events (MACE) compared to those with lower ratios.