The American journal of gastroenterology · 2026
Nociplastic Pain is Associated With Increased Healthcare Utilization and Lower Quality of Life in Patients With Inflammatory Bowel Disease.
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Sheehan Jessica L, Clauw Daniel J, Singh Prashant, Lee Allen, Bishu Shrinivas, Johnson Laura A, Higgins Peter D R
Аннотация
INTRODUCTION: Nociplastic pain (NP) may cause persistent abdominal pain despite well-controlled inflammation in inflammatory bowel disease (IBD).
METHODS: Five hundred patients with IBD were retrospectively classified as acute IBD-related pain, chronic IBD-related pain, or NP. Multivariable regression identified factors associated with NP and differences in healthcare use, symptoms, and quality of life (QoL).
RESULTS: NP occurred in 15% of patients with IBD and was associated with female sex, anxiety, depression, and higher social vulnerability. NP patients had more healthcare use and poorer QoL.
DISCUSSION: NP is common in IBD and linked to psychosocial comorbidity, higher healthcare use, and reduced QoL.
METHODS: Five hundred patients with IBD were retrospectively classified as acute IBD-related pain, chronic IBD-related pain, or NP. Multivariable regression identified factors associated with NP and differences in healthcare use, symptoms, and quality of life (QoL).
RESULTS: NP occurred in 15% of patients with IBD and was associated with female sex, anxiety, depression, and higher social vulnerability. NP patients had more healthcare use and poorer QoL.
DISCUSSION: NP is common in IBD and linked to psychosocial comorbidity, higher healthcare use, and reduced QoL.