The Kurume medical journal · 2026
The Effects of Hyperbaric Oxygen Therapy in Postoperative Patients with Ulcerative Colitis: A Retrospective Study.
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Muroya Daisuke, Nadayoshi Shinya, Yamada Koito, Kai Yutaro, Masuda Tetsu, Miyazaki Daiki, Sasaki Shin, Shimokobe Hisaaki, Shimokobe Hisao, Okamoto Kenji, Hiramatsu Toshiki, Inoue Masao, Konno Takeshi, Okamoto Kohji
Аннотация
OBJECTIVES: Numerous clinical trials have proven that hyperbaric oxygen therapy (HBOT) is an effective adjunctive treatment for inflammatory bowel disease (IBD). The present study evaluated the effect of HBOT in patients with postoperative ulcerative colitis (UC).
METHODS: This retrospective study examined the effects of HBOT on short-term postoperative outcomes in patients with UC. This study included 21 patients with postoperative UC between January 2013 and December 2023. Of these, six patients received HBOT; the previous indication for HBOT was postoperative ileus. The nutritional status, inflammatory findings, and disease severity scores were evaluated during the one-month post-operative period.
RESULTS: In the univariate analysis, the mean age was higher in the non-HBOT group than in the HBOT group (54.3 vs. 64.9 years old, p=0.0461), although the operative details and severity did not differ markedly. The usefulness of the Controlling Nutritional Status (CONUT) score as a nutritional screening and predictive tool has been demonstrated for various inflammatory and neoplastic diseases, including UC. The CONUT score was inversely correlated with Onodera's prognostic nutritional index and positively correlated with the platelet count, C-reactive protein level, and erythrocyte sedimentation rate. In addition, the HBOT group had a lower CONUT score 1 month after surgery than the non-HBOT group (2.0 vs. 4.4, p= 0.0190).
CONCLUSIONS: Postoperative UC patients who received HBOT had better CONUT scores at 1 month compared to those who did not.
METHODS: This retrospective study examined the effects of HBOT on short-term postoperative outcomes in patients with UC. This study included 21 patients with postoperative UC between January 2013 and December 2023. Of these, six patients received HBOT; the previous indication for HBOT was postoperative ileus. The nutritional status, inflammatory findings, and disease severity scores were evaluated during the one-month post-operative period.
RESULTS: In the univariate analysis, the mean age was higher in the non-HBOT group than in the HBOT group (54.3 vs. 64.9 years old, p=0.0461), although the operative details and severity did not differ markedly. The usefulness of the Controlling Nutritional Status (CONUT) score as a nutritional screening and predictive tool has been demonstrated for various inflammatory and neoplastic diseases, including UC. The CONUT score was inversely correlated with Onodera's prognostic nutritional index and positively correlated with the platelet count, C-reactive protein level, and erythrocyte sedimentation rate. In addition, the HBOT group had a lower CONUT score 1 month after surgery than the non-HBOT group (2.0 vs. 4.4, p= 0.0190).
CONCLUSIONS: Postoperative UC patients who received HBOT had better CONUT scores at 1 month compared to those who did not.