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Leukemia · 2022

Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.

СтатьяResearch Support, N.I.H., IntramuralПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Berndt Sonja I, Vijai Joseph, Benavente Yolanda, Camp Nicola J, Nieters Alexandra, Wang Zhaoming, Smedby Karin E, Kleinstern Geffen, Hjalgrim Henrik, Besson Caroline, Skibola Christine F, Morton Lindsay M, Brooks-Wilson Angela R, Teras Lauren R, Breeze Charles, Arias Joshua, Adami Hans-Olov, Albanes Demetrius, Anderson Kenneth C, Ansell Stephen M, Bassig Bryan, Becker Nikolaus, Bhatti Parveen, Birmann Brenda M, Boffetta Paolo, Bracci Paige M, Brennan Paul, Brown Elizabeth E, Burdett Laurie, Cannon-Albright Lisa A, Chang Ellen T, Chiu Brian C H, Chung Charles C, Clavel Jacqueline, Cocco Pierluigi, Colditz Graham, Conde Lucia, Conti David V, Cox David G, Curtin Karen, Casabonne Delphine, De Vivo Immaculata, Diepstra Arjan, Diver W Ryan, Dogan Ahmet, Edlund Christopher K, Foretova Lenka, Fraumeni Joseph F, Gabbas Attilio, Ghesquières Hervé, Giles Graham G, Glaser Sally, Glenn Martha, Glimelius Bengt, Gu Jian, Habermann Thomas M, Haiman Christopher A, Haioun Corinne, Hofmann Jonathan N, Holford Theodore R, Holly Elizabeth A, Hutchinson Amy, Izhar Aalin, Jackson Rebecca D, Jarrett Ruth F, Kaaks Rudolph, Kane Eleanor, Kolonel Laurence N, Kong Yinfei, Kraft Peter, Kricker Anne, Lake Annette, Lan Qing, Lawrence Charles, Li Dalin, Liebow Mark, Link Brian K, Magnani Corrado, Maynadie Marc, McKay James, Melbye Mads, Miligi Lucia, Milne Roger L, Molina Thierry J, Monnereau Alain, Montalvan Rebecca, North Kari E, Novak Anne J, Onel Kenan, Purdue Mark P, Rand Kristin A, Riboli Elio, Riby Jacques, Roman Eve, Salles Gilles, Sborov Douglas W, Severson Richard K, Shanafelt Tait D, Smith Martyn T, Smith Alexandra, Song Kevin W, Song Lei, Southey Melissa C, Spinelli John J, Staines Anthony, Stephens Deborah, Sutherland Heather J, Tkachuk Kaitlyn, Thompson Carrie A, Tilly Hervé, Tinker Lesley F, Travis Ruth C, Turner Jenny, Vachon Celine M, Vajdic Claire M, Van Den Berg Anke, Van Den Berg David J, Vermeulen Roel C H, Vineis Paolo, Wang Sophia S, Weiderpass Elisabete, Weiner George J, Weinstein Stephanie, Doo Nicole Wong, Ye Yuanqing, Yeager Meredith, Yu Kai, Zeleniuch-Jacquotte Anne, Zhang Yawei, Zheng Tongzhang, Ziv Elad, Sampson Joshua, Chatterjee Nilanjan, Offit Kenneth, Cozen Wendy, Wu Xifeng, Cerhan James R, Chanock Stephen J, Slager Susan L, Rothman Nathaniel

Аннотация

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting shared genetic susceptibility across subtypes. To evaluate the extent of mutual heritability among NHL subtypes and discover novel loci shared among subtypes, we analyzed data from eight genome-wide association studies within the InterLymph Consortium, including 10,629 cases and 9505 controls. We utilized Association analysis based on SubSETs (ASSET) to discover loci for subsets of NHL subtypes and evaluated shared heritability across the genome using Genome-wide Complex Trait Analysis (GCTA) and polygenic risk scores. We discovered 17 genome-wide significant loci (P < 5 × 10-8) for subsets of NHL subtypes, including a novel locus at 10q23.33 (HHEX) (P = 3.27 × 10-9). Most subset associations were driven primarily by only one subtype. Genome-wide genetic correlations between pairs of subtypes varied broadly from 0.20 to 0.86, suggesting substantial heterogeneity in the extent of shared heritability among subtypes. Polygenic risk score analyses of established loci for different lymphoid malignancies identified strong associations with some NHL subtypes (P < 5 × 10-8), but weak or null associations with others. Although our analyses suggest partially shared heritability and biological pathways, they reveal substantial heterogeneity among NHL subtypes with each having its own distinct germline genetic architecture.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты