Treatment of cerebral coenuriosis in sheep with praziquantel.

Sheep (n = 14) with coenuriosis were treated with praziquantel in single or divided doses at total dosage rates of 50 to 500 mg kg-1 live mass. Nine of the sheep also received corticosteroid, diuretic and analgesic supportive therapy. Stress was avoided as far as practically possible. Treatment of one sheep with acute coenuriosis at a total dosage rate of 500 mg kg-1 praziquantel, was unsuccessful. Eight sheep were successfully treated at total dosages ranging from 100 to 500 mg kg-1 live mass, whereas dosages of 50 mg kg-1 were successful in 2 sheep only. Dosages of 50 mg kg-1 in 2 other sheep with multiple cerebral coenuri, were unsuccessful or only partially successful in killing parasites.