Movement disorders : official journal of the Movement Disorder Society · 2013
Caffeine consumption and risk of dyskinesia in CALM-PD.
СтатьяМногоцентровое исследованиеРандомизированное исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Wills Anne-Marie A, Eberly Shirley, Tennis Marsha, Lang Anthony E, Messing Susan, Togasaki Daniel, Tanner Caroline M, Kamp Cornelia, Chen Jiang-Fan, Oakes David, McDermott Michael P, Schwarzschild Michael A, Parkinson Study Group
Аннотация
BACKGROUND: Adenosine A2A receptor antagonists reduce or prevent the development of dyskinesia in animal models of levodopa-induced dyskinesia.
METHODS: We examined the association between self-reported intake of the A2A receptor antagonist caffeine and time to dyskinesia in the Comparison of the Agonist Pramipexole with Levodopa on Motor Complications of Parkinson's Disease (CALM-PD) and CALM Cohort extension studies, using a Cox proportional hazards model adjusting for age, baseline Parkinson's severity, site, and initial treatment with pramipexole or levodopa.
RESULTS: For subjects who consumed >12 ounces of coffee/day, the adjusted hazard ratio for the development of dyskinesia was 0.61 (95% CI, 0.37-1.01) compared with subjects who consumed <4 ounces/day. For subjects who consumed between 4 and 12 ounces/day, the adjusted hazard ratio was 0.73 (95% CI, 0.46-1.15; test for trend, P = .05).
CONCLUSIONS: These results support the possibility that caffeine may reduce the likelihood of developing dyskinesia.
METHODS: We examined the association between self-reported intake of the A2A receptor antagonist caffeine and time to dyskinesia in the Comparison of the Agonist Pramipexole with Levodopa on Motor Complications of Parkinson's Disease (CALM-PD) and CALM Cohort extension studies, using a Cox proportional hazards model adjusting for age, baseline Parkinson's severity, site, and initial treatment with pramipexole or levodopa.
RESULTS: For subjects who consumed >12 ounces of coffee/day, the adjusted hazard ratio for the development of dyskinesia was 0.61 (95% CI, 0.37-1.01) compared with subjects who consumed <4 ounces/day. For subjects who consumed between 4 and 12 ounces/day, the adjusted hazard ratio was 0.73 (95% CI, 0.46-1.15; test for trend, P = .05).
CONCLUSIONS: These results support the possibility that caffeine may reduce the likelihood of developing dyskinesia.
Предметные рубрики MeSH
Adenosine A2 Receptor AntagonistsAgedAntiparkinson AgentsBenzothiazolesCaffeineCohort StudiesDose-Response Relationship, DrugDouble-Blind MethodDyskinesia, Drug-InducedFemaleHumansKaplan-Meier EstimateLevodopaMaleMiddle AgedParkinson DiseasePramipexoleProportional Hazards ModelsRetrospective StudiesRisk