Rheumatology (Oxford, England) · 2025
Diagnostic value of a novel salivary gland ultrasound scoring system in IgG4-related sialadenitis.
Оценочное исследованиеСтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Zhou Mingzhu, Liu Yanying, Zhang Shanshan, Xie Xiaoyan, Li Wei, Cui Li, Zhao Hanxue, Tang Sumei, Hu Xiangdong, Wu Shanshan, Peng Jiajing, Huang Huilian, Ren Wei, Zhang Ying, Xu Ning, Sun Pengfei, Liu Yiqun, Zhang Zuyan, Yu Guangyan, Su Yin
Аннотация
OBJECTIVES: To develop a novel ultrasound scoring system for the major salivary glands in patients with immunoglobulin G4-related sialadenitis (IgG4-RS) and assess its diagnostic value in a multicentre cohort of Chinese patients.
METHODS: Twenty clinicians (rheumatologists, stomatologists and radiologists) participated. The study was conducted in four steps: (i) defining the ultrasonography (US) elements, (ii) developing a novel ultrasound scoring system for US of the salivary glands, (iii) evaluation of inter- and intra-reader reliabilities using the new ultrasound scoring system, and (iv) assessing the diagnostic value of this novel ultrasound scoring system in IgG4-RS patients in a Chinese multicentre cohort.
RESULTS: A novel ultrasound scoring system for the salivary glands was developed, with total scores ranging from 0 to 34. The inter- and intra-reader reliabilities of the ultrasound scoring system were excellent (0.972 and 0.940, respectively). A total of 470 people were recruited in this study; 187 patients were diagnosed with IgG4-RS, and the remaining 283 people were diagnosed with non-IgG4-RS. Patients with IgG4-RS group had significantly higher US scores than the non-IgG4-RS group (mean US score = 16 vs 4, P < 0.001). The calculated area under the curve for the total US score was 0.852 (95% CI: 0.814, 0.891). The total US scores ≥9 showed a sensitivity of 75.4% and a specificity of 91.9%. Association analysis showed a positive correlation between total US scores and serum IgG4 levels and hypocomplementaemia (r = 0.221 and r = 0.349, respectively; P = 0.002 and P < 0.001, respectively) and a negative correlation between total US scores and serum C3 and C4 levels (r = -0.210 and r = -0.303, respectively; P = 0.005 and P < 0.001, respectively).
CONCLUSION: A novel semiquantitative ultrasound scoring system for patients with IgG4-RS was developed, with good diagnostic performance. The inter- and intra-reader reliabilities were excellent. US scores were correlated with IgG4, C3 and C4 levels and hypocomplementaemia.
METHODS: Twenty clinicians (rheumatologists, stomatologists and radiologists) participated. The study was conducted in four steps: (i) defining the ultrasonography (US) elements, (ii) developing a novel ultrasound scoring system for US of the salivary glands, (iii) evaluation of inter- and intra-reader reliabilities using the new ultrasound scoring system, and (iv) assessing the diagnostic value of this novel ultrasound scoring system in IgG4-RS patients in a Chinese multicentre cohort.
RESULTS: A novel ultrasound scoring system for the salivary glands was developed, with total scores ranging from 0 to 34. The inter- and intra-reader reliabilities of the ultrasound scoring system were excellent (0.972 and 0.940, respectively). A total of 470 people were recruited in this study; 187 patients were diagnosed with IgG4-RS, and the remaining 283 people were diagnosed with non-IgG4-RS. Patients with IgG4-RS group had significantly higher US scores than the non-IgG4-RS group (mean US score = 16 vs 4, P < 0.001). The calculated area under the curve for the total US score was 0.852 (95% CI: 0.814, 0.891). The total US scores ≥9 showed a sensitivity of 75.4% and a specificity of 91.9%. Association analysis showed a positive correlation between total US scores and serum IgG4 levels and hypocomplementaemia (r = 0.221 and r = 0.349, respectively; P = 0.002 and P < 0.001, respectively) and a negative correlation between total US scores and serum C3 and C4 levels (r = -0.210 and r = -0.303, respectively; P = 0.005 and P < 0.001, respectively).
CONCLUSION: A novel semiquantitative ultrasound scoring system for patients with IgG4-RS was developed, with good diagnostic performance. The inter- and intra-reader reliabilities were excellent. US scores were correlated with IgG4, C3 and C4 levels and hypocomplementaemia.