The effects of rehabilitative training on the behaviors of Parkinson's disease mouse and underlying mechanism.

OBJECTIVE

To examine the effects of rehabilitative training on mice behavior improvement in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) mice model of Parkinson's disease (PD).

METHODS

MPTP mice model of Parkinson disease was generated. The rehabilitative training included daily running wheel and balance walking; the control group was allowed for free activity. The behaviors of the two groups were investigated at 1 week, 2 weeks, and 4 weeks and the content of dopamine (DA) in striatum of different groups of mice was measured with high-performance liquid chromatography (HPLC).

RESULTS

The results showed that as compared to the control group, the score of climbing pole, traction, swimming tests, and dopamine content was improved in the rehabilitative training group.

CONCLUSION

This suggested that rehabilitative training could improve the locomotor ability and dopamine content in PD mouse model.