Parallel supramammillary-hippocampal routes: Organization, dysregulation, and restoration.

In this issue of Neuron, Luo et al.1 report two supramammillary neuronal populations with segregated projections to the dorsal and ventral dentate gyrus that selectively modulate cognitive and emotional processes, respectively. Targeted activation of each pathway alleviates domain-specific behavioral deficits in an Alzheimer's disease mouse model.