Terapevticheskii arkhiv · 2009
[Clinical features of different variants of excretory pancreatic insufficiency].
СтатьяНазвание и аннотация: Оригинал на русском
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Osipenko M F, Venzhina Iu Iu
Аннотация
AIM: To analyse course of excretory pancreatic insufficiency (EPI) of pancreatic and not origin as well as factors associated with its development.
MATERIAL AND METHODS: A total of 139 patients with chronic pancreatitis or malabsorption were examined. The pancreatic function was assessed by the results of elastase test - concentration of pancreatic elastase 1 in the feces. EPI was detected in 57 patients (fecal pancreatic elastase 1 under 200 mcg/g); 38 patients had chronic pancreatitis and absolute EPI, 19 patients had relative EPI (the elastase was low, pancreatic pathology was absent, but other gastroenterological diseases were present--enteropathy, Crohn's disease, previous surgery).
RESULTS: Pancreatic insufficiency in patients with pancreatitis was 36.5%. It was associated with the disease duration. Diarrheal and asthenic syndromes, normal or low lipase levels in the serum were found. Patients with relative insufficiency were significantly younger, had shorter disease duration, more frequent diarrhea, were thinner. Correction of diarrheal syndrome was more successful in patients with absolute insufficiency. Pancreatic elastase concentration in the feces persisted for a year in patients with absolute EPI and normalized in patients with enteropathies after etiotropic and pathogenetic therapy.
MATERIAL AND METHODS: A total of 139 patients with chronic pancreatitis or malabsorption were examined. The pancreatic function was assessed by the results of elastase test - concentration of pancreatic elastase 1 in the feces. EPI was detected in 57 patients (fecal pancreatic elastase 1 under 200 mcg/g); 38 patients had chronic pancreatitis and absolute EPI, 19 patients had relative EPI (the elastase was low, pancreatic pathology was absent, but other gastroenterological diseases were present--enteropathy, Crohn's disease, previous surgery).
RESULTS: Pancreatic insufficiency in patients with pancreatitis was 36.5%. It was associated with the disease duration. Diarrheal and asthenic syndromes, normal or low lipase levels in the serum were found. Patients with relative insufficiency were significantly younger, had shorter disease duration, more frequent diarrhea, were thinner. Correction of diarrheal syndrome was more successful in patients with absolute insufficiency. Pancreatic elastase concentration in the feces persisted for a year in patients with absolute EPI and normalized in patients with enteropathies after etiotropic and pathogenetic therapy.