Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2009
Mature dendritic cells in inflamed human pulps beneath deep caries.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
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Harmon Melissa A, Tew John G, Best Al M, Hahn Chin-Lo
Аннотация
OBJECTIVE: Dendritic cells (DCs) in pulps have been identified with markers for immature DCs and the relationship of DC maturity to pulpal health has not been carefully examined. We sought to test the hypothesis that the frequency of CD83+ mature DCs would correlate with caries invasion.
STUDY DESIGN: Pulps were collected from extracted teeth exhibiting (I) no caries (n = 9), (II) shallow dentinal caries (n = 5), and (III) deep caries (n = 9). Immature DCs (CD209+), mature DCs (CD83+), and monocytes/macrophages (CD14+) in three groups were enumerated immunohistochemically.
RESULTS: Mature DCs were frequently found beneath deep caries (21.3 mature DCs/3 grids versus <1 in groups I and II) with increasing numbers of CD209+ DCs and CD14+ cells. Co-localization of CD4+ T cells with mature DCs and macrophages was observed in deep caries.
CONCLUSION: Mature DCs were frequently found only beneath deep caries and these DCs were co-localized with CD4+ T cells suggesting antigen presentation.
STUDY DESIGN: Pulps were collected from extracted teeth exhibiting (I) no caries (n = 9), (II) shallow dentinal caries (n = 5), and (III) deep caries (n = 9). Immature DCs (CD209+), mature DCs (CD83+), and monocytes/macrophages (CD14+) in three groups were enumerated immunohistochemically.
RESULTS: Mature DCs were frequently found beneath deep caries (21.3 mature DCs/3 grids versus <1 in groups I and II) with increasing numbers of CD209+ DCs and CD14+ cells. Co-localization of CD4+ T cells with mature DCs and macrophages was observed in deep caries.
CONCLUSION: Mature DCs were frequently found only beneath deep caries and these DCs were co-localized with CD4+ T cells suggesting antigen presentation.
Предметные рубрики MeSH
Antigen PresentationAntigens, CDCD4-Positive T-LymphocytesCell Adhesion MoleculesCell CountDendritic CellsDental CariesHumansImmunoglobulinsImmunohistochemistryLectins, C-TypeLipopolysaccharide ReceptorsMacrophagesMembrane GlycoproteinsMonocytesPulpitisReceptors, Cell SurfaceCD83 AntigenDC-Specific ICAM-3 Grabbing Nonintegrin