Bulletin of experimental biology and medicine · 2011
Changes in the concentration of monocytic chemotaxic protein-1 in patients with unstable angina treated with arixtra.
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Potekhina A V, Arefieva T I, Krasnikova T L, Provatorov S I, Masenko V P, Osyaeva M K, Noeva E A
Аннотация
The time course of inflammatory reaction markers in the blood of patients with unstable angina was studied during therapy including arixtra. Plasma concentration of monocytic chemotaxic protein-1 (MCP-1) decreased on days 2 and 3 in patients receiving arixtra and a trend to an increase in MCP-1 concentration was observed on day 7 after the drug was discontinued. After 1 month, MCP-1 level decreased in all patients. The concentration of highly sensitive C-reactive protein also decreased 1 month after the disease onset; no changes in the concentrations of IL-8 and IL-2 receptor α-subunit were detected during these periods. It seems that arixtra is characterized by an anti-inflammatory effect manifesting by reduction of plasma chemokine MCP-1 concentration.