Tumori · 1996
Sucralfate prophylaxis of fluorouracil-induced stomatitis.
Клиническое исследованиеКлиническое исследование II фазыСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Giorgi F, Bascioni R, De Signoribus G, Di Saverio F
Аннотация
AIMS AND BACKGROUND: Various attempts have been made to prevent 5-fluorouracil-induced stomatitis, with unsatisfactory results. Sucralfate is an aluminum hydroxide complex of sulfated sucrose commonly used in the treatment of gastroduodenal ulcers. We used the compound in a phase II study to reduce and minimize the stomatotoxicity of 5-fluorouracil chemotherapy administered in a multiple-day schedule.
METHODS: Fifty-two patients entered the study, and 129 cycles of chemotherapy were evaluated. Seven patients refused sucralfate rinses for taste intolerance.
RESULTS: A low level of stomatotoxicity was recorded: grade 2 stomatitis was observed after 14 cycles (10.8%) and grade 3 after 3 cycles (2.3%).
CONCLUSIONS: Sucralfate administration could have a role in the prevention of 5-fluorouracil-induced stomatitis.
METHODS: Fifty-two patients entered the study, and 129 cycles of chemotherapy were evaluated. Seven patients refused sucralfate rinses for taste intolerance.
RESULTS: A low level of stomatotoxicity was recorded: grade 2 stomatitis was observed after 14 cycles (10.8%) and grade 3 after 3 cycles (2.3%).
CONCLUSIONS: Sucralfate administration could have a role in the prevention of 5-fluorouracil-induced stomatitis.