Minerva gastroenterology · 2026
Association of Endothelial Activation and Stress Index with mortality in hepatitis B patients: insights from NHANES.
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Yu Siyu, Ji Cheng
Аннотация
BACKGROUND: This investigation was to assess the association between endothelial activation and stress index (EASIX) levels and mortality risk in hepatitis B virus (HBV)-infected patients.
METHODS: This retrospective study analyzed HBV-infected adults from the National Health and Nutrition Examination Survey database. Weighted univariate and multivariate Cox regression models analyzed the relationship between EASIX and all-cause mortality. Kaplan-Meier curves and restricted cubic spline curves supplemented these findings, while the concordance index (C-index) assessed EASIX's predictive accuracy.
RESULTS: The analysis comprised 3468 patients. The analysis revealed that elevated EASIX levels correlated with higher all-cause mortality risk in HBV patients (continuous: hazard ratio [HR] 1.07, 95% CI: 1.02-1.12; categorical: HR=1.52, 95% CI: 1.17-1.99). Patients with higher EASIX levels had a lower probability of survival (P<0.05). A nonlinear correlation was found between elevated EASIX scores and poorer survival outcomes (P<0.05). EASIX showed moderate predictive accuracy, with C-index values of 0.646 (95% CI: 0.611-0.680).
CONCLUSIONS: EASIX performed a moderate discriminative ability for mortality risk in HBV-infected patients, suggesting a complementary prognostic value with conventional liver fibrosis indices and established scores.
METHODS: This retrospective study analyzed HBV-infected adults from the National Health and Nutrition Examination Survey database. Weighted univariate and multivariate Cox regression models analyzed the relationship between EASIX and all-cause mortality. Kaplan-Meier curves and restricted cubic spline curves supplemented these findings, while the concordance index (C-index) assessed EASIX's predictive accuracy.
RESULTS: The analysis comprised 3468 patients. The analysis revealed that elevated EASIX levels correlated with higher all-cause mortality risk in HBV patients (continuous: hazard ratio [HR] 1.07, 95% CI: 1.02-1.12; categorical: HR=1.52, 95% CI: 1.17-1.99). Patients with higher EASIX levels had a lower probability of survival (P<0.05). A nonlinear correlation was found between elevated EASIX scores and poorer survival outcomes (P<0.05). EASIX showed moderate predictive accuracy, with C-index values of 0.646 (95% CI: 0.611-0.680).
CONCLUSIONS: EASIX performed a moderate discriminative ability for mortality risk in HBV-infected patients, suggesting a complementary prognostic value with conventional liver fibrosis indices and established scores.