Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2016
Long-term prognostic significance of homocysteine in middle-aged and elderly.
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Petersen Julie Falkenberg, Larsen Bjørn Strøjer, Sabbah Muhammad, Nielsen Olav Wendelboe, Kumarathurai Preman, Sajadieh Ahmad
Аннотация
OBJECTIVE: We investigated the association among increased levels of plasma homocysteine (Hcy), all-cause mortality, and cardiovascular events.
METHODS: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.
RESULTS: Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.
CONCLUSION: Increased levels of Hcy are associated with all-cause mortality and CV events.
METHODS: Hcy was measured in 670 middle-aged and elderly subjects with no previous manifest cardiovascular disease. The follow-up period was 15 years.
RESULTS: Subjects with Hcy ≥ 10.8 μmol/l (n = 231) had a significant higher incidence of all-cause mortality (p < 0.001) and CV events (p < 0.001) compared with subjects with Hcy < 10.8 μmol/l (n = 439). However, there was no association on high levels of Hcy and VTE events or stroke.
CONCLUSION: Increased levels of Hcy are associated with all-cause mortality and CV events.