Alteration in some hepatic dehydrogenases and certain lipid components in thiamin deficiency.

An investigation was conducted to study the influence of thiamin deficiency on hepatic glucose-6-phosphate dehydrogenase, malic enzyme (NADP), lactate dehydrogenase and it's isoenzymes, total lipids, cholesterol and phospholipids in adult male albino rats. Typical thiamin deficiency symptoms developed in the 6th week. The specific activity of the said enzymes was significantly decreased in deficient rats as compared to pairfed controls. A significant drop in total lipid and phospholipid content was noted in deficient group while total cholesterol remained unchanged. Refeeding of control diet to deficient animals caused reversal of enzyme activities to normal.