Successful treatment of typhoid fever with a single dose of ceftriaxone for one or two days.

The therapeutic efficacy of ceftriaxone was evaluated in variable dose and duration schedules in twenty patients with bacteriologically proven typhoid fever. The results were satisfactory in the cases that were given a single dose of 3 g for two days (12/12) or 4 g for one day (3/4). Some untoward reactions were observed in 8 cases, but it was not clinically significant. Ceftriaxone appears to be safe and effective in the treatment of typhoid fever when administered in a single dose of 4 g for one day or 3 g for two days on an outpatients basis.