Head & neck · 2018
Predictors of thyroxine replacement following hemithyroidectomy in a south east Asian cohort.
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Ng Peng, Ho Cheryl, Tan Wee Boon, Ngiam Kee Yuan, Lim Chwee Ming, Thomas Loh Kwok Seng, Nga Min En, Parameswaran Rajeev
Аннотация
BACKGROUND: Thyroxine replacement following a hemithyroidectomy is not commonly discussed during consent for the procedure as the risk of hypothyroidism is perceived to be low.
METHODS: Retrospective review of 901 patients who underwent hemithyroidectomy at a tertiary referral institution during the period January 2000 to December 2015. The main outcome studied was the overall incidence of hypothyroidism and the associated risk factors.
RESULTS: Hypothyroidism developed in 123 (13%) patients and 94 patients (10%) required hormone supplementation over a mean follow up of 21 months (range 1-168 months). Preoperative TSH of more than 2.5 was seen in 38 of 123 (31%) of patients. Presence of diffuse thyroiditis was the only independent risk factor on multivariate analysis (P = 0.002) found to be associated with the development of hypothyroidism.
CONCLUSION: After thyroid lobectomy, approximately one in 10 patients requiring thyroid hormone treatment for hypothyroidism. Presence of diffuse thyroiditis is a significant risk factor for hypothyroidism.
METHODS: Retrospective review of 901 patients who underwent hemithyroidectomy at a tertiary referral institution during the period January 2000 to December 2015. The main outcome studied was the overall incidence of hypothyroidism and the associated risk factors.
RESULTS: Hypothyroidism developed in 123 (13%) patients and 94 patients (10%) required hormone supplementation over a mean follow up of 21 months (range 1-168 months). Preoperative TSH of more than 2.5 was seen in 38 of 123 (31%) of patients. Presence of diffuse thyroiditis was the only independent risk factor on multivariate analysis (P = 0.002) found to be associated with the development of hypothyroidism.
CONCLUSION: After thyroid lobectomy, approximately one in 10 patients requiring thyroid hormone treatment for hypothyroidism. Presence of diffuse thyroiditis is a significant risk factor for hypothyroidism.
Предметные рубрики MeSH
AdultAgedCohort StudiesAsia, EasternFemaleHormone Replacement TherapyHumansHypothyroidismMaleMiddle AgedMultivariate AnalysisPostoperative ComplicationsPredictive Value of TestsPrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentThyroid Function TestsThyroid NeoplasmsThyroidectomyThyroiditisThyroxineTreatment Outcome