Head & neck · 2016
Management of the clinically N0 neck in squamous cell carcinoma of the maxillary alveolus and hard palate.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Os Alejandra D van, Karakullukcu Baris, Leemans C René, Halmos Gyorgy B, Roodenburg Jan L N, Weert Stijn van, Karagozoglu K Hakki, Witjes Max J H
Аннотация
BACKGROUND: The purpose of this study was to evaluate active surveillance strategy in the clinically negative neck in maxillary squamous cell carcinoma (SCC).
METHODS: One hundred fourteen consecutive patients diagnosed with oral maxillary SCC were analyzed retrospectively from 3 centers in The Netherlands. Analysis parameters included regional disease-free survival of N0 patients stratified for T classification, elective radiotherapy (RT) of the neck; and overall survival of the whole cohort, stratified by N classification; salvage neck surgery rates.
RESULTS: Within the N0 cohort, 26.0% of the patients developed neck metastasis in the follow-up visits. Regional recurrence was not related to T classification or postoperative RT of the neck. Regional and locoregional recurrence were associated with diminished overall survival (p < .05). Regional metastasis was operable in 22 of 26 cases (85%). Only 1 patient presented with inoperable neck metastasis without local recurrence.
CONCLUSION: Watchful waiting was feasible in this cohort. If meticulous follow-up is not available, elective neck dissection is recommended. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1794-1798, 2016.
METHODS: One hundred fourteen consecutive patients diagnosed with oral maxillary SCC were analyzed retrospectively from 3 centers in The Netherlands. Analysis parameters included regional disease-free survival of N0 patients stratified for T classification, elective radiotherapy (RT) of the neck; and overall survival of the whole cohort, stratified by N classification; salvage neck surgery rates.
RESULTS: Within the N0 cohort, 26.0% of the patients developed neck metastasis in the follow-up visits. Regional recurrence was not related to T classification or postoperative RT of the neck. Regional and locoregional recurrence were associated with diminished overall survival (p < .05). Regional metastasis was operable in 22 of 26 cases (85%). Only 1 patient presented with inoperable neck metastasis without local recurrence.
CONCLUSION: Watchful waiting was feasible in this cohort. If meticulous follow-up is not available, elective neck dissection is recommended. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1794-1798, 2016.
Предметные рубрики MeSH
AdultAgedAged, 80 and overCarcinoma, Squamous CellCohort StudiesCombined Modality TherapyDisease-Free SurvivalFemaleHumansLymph NodesLymphatic MetastasisMaleMaxillary NeoplasmsMiddle AgedNeckNeoplasm InvasivenessNeoplasm StagingNetherlandsPalatal NeoplasmsPrognosisRetrospective StudiesRisk AssessmentSurvival AnalysisWatchful Waiting