Intestinal Failure (New York, N.Y.) · 2026
Wet beriberi in intestinal failure due to change from intravenous to enteral supplementation - Time to focus on water-soluble vitamins.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Loel Benjamin, Fox Julia, Zajac Katie, Ee Looi, Hind Jonathan
Аннотация
BACKGROUND: Thiamine deficiency is a rare but life-threatening complication for which children on long term parenteral nutrition (PN) are at higher risk.
CASE REPORT: We describe a 13-year-old male with intestinal failure secondary to Filamin A mutation who presented with one-week of oedema and orthopnoea. He was fully dependent on PN and his intravenous multivitamin supplementation was replaced with enteral vitamins due to a national shortage. On presentation he was tachycardic, tachypnoeic, hypotensive, and fluid overloaded. Investigations revealed hyponatraemia, hypoalbuminaemia, metabolic acidosis, and a significantly elevated lactate. Chest radiography showed bilateral pleural effusions. Intravenous thiamine and oral vitamin C supplementation led to rapid clinical improvement and testing confirmed low thiamine and vitamin C levels. His presentation was consistent with wet beriberi due to thiamine deficiency.
CONCLUSION: This case highlights the risk of water-soluble vitamin deficiency in PN-dependent children during intravenous vitamin shortages and the need for biochemical monitoring.
CASE REPORT: We describe a 13-year-old male with intestinal failure secondary to Filamin A mutation who presented with one-week of oedema and orthopnoea. He was fully dependent on PN and his intravenous multivitamin supplementation was replaced with enteral vitamins due to a national shortage. On presentation he was tachycardic, tachypnoeic, hypotensive, and fluid overloaded. Investigations revealed hyponatraemia, hypoalbuminaemia, metabolic acidosis, and a significantly elevated lactate. Chest radiography showed bilateral pleural effusions. Intravenous thiamine and oral vitamin C supplementation led to rapid clinical improvement and testing confirmed low thiamine and vitamin C levels. His presentation was consistent with wet beriberi due to thiamine deficiency.
CONCLUSION: This case highlights the risk of water-soluble vitamin deficiency in PN-dependent children during intravenous vitamin shortages and the need for biochemical monitoring.