Clinica chimica acta; international journal of clinical chemistry · 2013
Utility of cystatin C as a marker for the severity of aortic regurgitation in hypertensive patients.
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Iida Masato, Yamamoto Mitsuru, Ishiguro Yuko S, Yamazaki Masatoshi, Ueda Norihiro, Honjo Haruo, Kamiya Kaichirou
Аннотация
BACKGROUND: Cystatin C, a cathepsin inhibitor, is involved in the remodeling of human aortic valve and left ventricle (LV).
OBJECTIVE: Cystatin C may be related to the severity of aortic regurgitation (AR).
METHODS: We measured cystatin C and CRP in hypertensive patients with mild-to-moderate AR (n=120) and in those without AR (n=128). Echocardiography was performed to assess the vena contracta width (the narrowest region of regurgitant jet, VCW) as a marker of the severity of AR, relative wall thickness as a marker of LV concentric remodeling, and the ratio of early peak mitral flow to early diastolic mitral annular velocity (E/e') as an index of LV diastolic function. Glomerular filtration rate (GFR) was estimated using the MDRD methods.
RESULTS: Cystatin C levels were greater in hypertensive patients with AR than in those without AR. A multiple linear regression analysis indicated cystatin C levels correlated with the VCW independent of GFR, body mass index, CRP, relative wall thickness, and E/e' in hypertensive patients with AR.
CONCLUSIONS: Cystatin C was associated with the severity of regurgitation independent of renal function body composition chronic inflammation LV remodeling and diastolic function in hypertensive patients with mild-to-moderate AR.
OBJECTIVE: Cystatin C may be related to the severity of aortic regurgitation (AR).
METHODS: We measured cystatin C and CRP in hypertensive patients with mild-to-moderate AR (n=120) and in those without AR (n=128). Echocardiography was performed to assess the vena contracta width (the narrowest region of regurgitant jet, VCW) as a marker of the severity of AR, relative wall thickness as a marker of LV concentric remodeling, and the ratio of early peak mitral flow to early diastolic mitral annular velocity (E/e') as an index of LV diastolic function. Glomerular filtration rate (GFR) was estimated using the MDRD methods.
RESULTS: Cystatin C levels were greater in hypertensive patients with AR than in those without AR. A multiple linear regression analysis indicated cystatin C levels correlated with the VCW independent of GFR, body mass index, CRP, relative wall thickness, and E/e' in hypertensive patients with AR.
CONCLUSIONS: Cystatin C was associated with the severity of regurgitation independent of renal function body composition chronic inflammation LV remodeling and diastolic function in hypertensive patients with mild-to-moderate AR.