Journal of drugs in dermatology : JDD · 2026
Beyond Efficacy: 0.6% Selenium Disulfide Shampoo Matches 2% Ketoconazole for Seborrheic Dermatitis with Superior Cosmesis.
СтатьяРандомизированное исследованиеСравнительное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Farris Patricia K, Barbosa Victoria, Houshmand Elizabeth Bahar, Kovylkina Natalia
Аннотация
BACKGROUND: Although most dandruff shampoos are effective, many leave hair dry and unmanageable, potentially impacting patient compliance and treatment outcomes.
OBJECTIVE: This study compared the efficacy, tolerability, and cosmetic benefits of 0.6% micronized selenium disulfide shampoo (SeS2) to 2% ketoconazole shampoo.
METHODS: Eighty-seven male and female subjects with moderate to severe dandruff participated in a single-center, 6-week, randomized, double-blind study comparing the benefits and attributes of the shampoos.
RESULTS: After 6 weeks of use, Total Scale Score (TSS) decreased by 69.5% in the ketoconazole group, and 77.9% in the SeS2 group, and Symptomatic Scale of Seborrheic Dermatitis (SSSD) decreased by 68.0% in the ketoconazole group and 74.5% in the SeS2 group (all P<0.001). Pruritus severity score decreased by 76.2% and 75.9% in the ketoconazole and SeS2 groups, respectively, and global efficacy and satisfaction, as assessed by blinded dermatologic evaluation, showed significant improvement with both products (all P<0.001). There was no significant difference between the two groups for these outcomes at any time point. Tolerability was excellent for both products. In terms of cosmesis, subjects across diverse curl types favored the SeS2 shampoo with significantly more agreeing that the SeS2 shampoo leaves hair soft, supple, glossy, natural appearing, and was suitable for their hair type when compared to ketoconazole (P<0.001).
CONCLUSION: This micronized 0.6% SeS2 shampoo is as effective as 2% ketoconazole shampoo for treating moderate to severe scalp seborrheic dermatitis and provides superior cosmetic benefits across diverse curl types.  .
OBJECTIVE: This study compared the efficacy, tolerability, and cosmetic benefits of 0.6% micronized selenium disulfide shampoo (SeS2) to 2% ketoconazole shampoo.
METHODS: Eighty-seven male and female subjects with moderate to severe dandruff participated in a single-center, 6-week, randomized, double-blind study comparing the benefits and attributes of the shampoos.
RESULTS: After 6 weeks of use, Total Scale Score (TSS) decreased by 69.5% in the ketoconazole group, and 77.9% in the SeS2 group, and Symptomatic Scale of Seborrheic Dermatitis (SSSD) decreased by 68.0% in the ketoconazole group and 74.5% in the SeS2 group (all P<0.001). Pruritus severity score decreased by 76.2% and 75.9% in the ketoconazole and SeS2 groups, respectively, and global efficacy and satisfaction, as assessed by blinded dermatologic evaluation, showed significant improvement with both products (all P<0.001). There was no significant difference between the two groups for these outcomes at any time point. Tolerability was excellent for both products. In terms of cosmesis, subjects across diverse curl types favored the SeS2 shampoo with significantly more agreeing that the SeS2 shampoo leaves hair soft, supple, glossy, natural appearing, and was suitable for their hair type when compared to ketoconazole (P<0.001).
CONCLUSION: This micronized 0.6% SeS2 shampoo is as effective as 2% ketoconazole shampoo for treating moderate to severe scalp seborrheic dermatitis and provides superior cosmetic benefits across diverse curl types.  .