Pharmacogenomics · 2016
Differences in genetic variants in lopinavir disposition among HIV-infected Bantu Africans.
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Mpeta Bafokeng, Kampira Elizabeth, Castel Sandra, Mpye Keleabetswe L, Soko Nyarai D, Wiesner Lubbe, Smith Peter, Skelton Michelle, Lacerda Miguel, Dandara Collet
Аннотация
INTRODUCTION: Variability in lopinavir (LPV) plasma concentration among patients could be due to genetic polymorphisms. This study set to evaluate significance of variants in CYP3A4/5, SLCO1B1 and ABCC2 on LPV plasma concentration among African HIV-positive patients.
MATERIALS & METHODS: Eighty-six HIV-positive participants on ritonavir (LPV/r) were genetically characterized and LPV plasma concentration determined.
RESULTS & DISCUSSION: LPV plasma concentrations differed >188-fold (range 0.0206-38.6 µg/ml). Both CYP3A4*22 and SLCO1B1 rs4149056G (c.521C) were not observed in this cohort. CYP3A4*1B, CYP3A5*3, CYP3A5*6 and ABCC2 c.1249G>A which have been associated with LPV plasma concentration, showed no significant association.
CONCLUSION: These findings highlight the need to include African groups in genomics research to identify variants of pharmacogenomics significance.
MATERIALS & METHODS: Eighty-six HIV-positive participants on ritonavir (LPV/r) were genetically characterized and LPV plasma concentration determined.
RESULTS & DISCUSSION: LPV plasma concentrations differed >188-fold (range 0.0206-38.6 µg/ml). Both CYP3A4*22 and SLCO1B1 rs4149056G (c.521C) were not observed in this cohort. CYP3A4*1B, CYP3A5*3, CYP3A5*6 and ABCC2 c.1249G>A which have been associated with LPV plasma concentration, showed no significant association.
CONCLUSION: These findings highlight the need to include African groups in genomics research to identify variants of pharmacogenomics significance.
Предметные рубрики MeSH
AdultAnti-HIV AgentsBlack PeopleCross-Sectional StudiesCytochrome P-450 CYP3AEthnicityFemaleHIV InfectionsHumansLiver-Specific Organic Anion Transporter 1LopinavirMaleMultidrug Resistance-Associated Protein 2ATP-Binding Cassette, Sub-Family C ProteinsPharmacogenomic VariantsPolymorphism, Single NucleotideYoung Adult