Annals of epidemiology · 2026
Non-tobacco nicotine use and the risk of cataract development.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Vu Pham Nathan, Dutta Emery, Nguyen Thalia H, Li Albert Y, Alsoudi Amer, Loya Asad
Аннотация
PURPOSE: To examine the relationship between non-tobacco nicotine product (NTNP) exposure and the risk of cataract development and cataract surgery.
DESIGN: A retrospective analysis of aggregated healthcare data within the TriNetX U.S. Collaborative Network METHODS: We identified patients with documented exposure to NTNPs (n = 107,462) and control patients (n = 2,512,152) without exposure. NTNP exposure was defined as having had a vaping-related or unspecified nicotine dependence diagnosis. Patients with pre-existing lens disorders, ocular trauma, or procedures were excluded. Propensity score matching (1:1) was performed, accounting for demographics, cataract risk factors, and comorbidities. We assessed the risk of developing cataracts and receiving cataract surgery. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated.
RESULTS: After PSM, the exposure and control groups had mean ages of 50.8 ± 15.7 vs 51.8 ± 16.8 years, 61% vs 62% White, and 50% vs 50% female. Compared to matched controls (n = 106,116), patients exposed to NTNPs (n = 106,116) had an increased risk of developing cataracts (HR 2.21; 95% CI 2.12-2.31). Of the patients who received a cataract diagnosis, NTNP exposure was associated with higher risk of receiving cataract surgery (HR 2.93; 95% CI 2.77-3.09) within 5 years.
CONCLUSION: NTNP usage may be associated with cataract development. Given their widespread use in recent years, they may pose considerable public health risks, and it would be prudent to further investigate their relationship with cataracts.
DESIGN: A retrospective analysis of aggregated healthcare data within the TriNetX U.S. Collaborative Network METHODS: We identified patients with documented exposure to NTNPs (n = 107,462) and control patients (n = 2,512,152) without exposure. NTNP exposure was defined as having had a vaping-related or unspecified nicotine dependence diagnosis. Patients with pre-existing lens disorders, ocular trauma, or procedures were excluded. Propensity score matching (1:1) was performed, accounting for demographics, cataract risk factors, and comorbidities. We assessed the risk of developing cataracts and receiving cataract surgery. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated.
RESULTS: After PSM, the exposure and control groups had mean ages of 50.8 ± 15.7 vs 51.8 ± 16.8 years, 61% vs 62% White, and 50% vs 50% female. Compared to matched controls (n = 106,116), patients exposed to NTNPs (n = 106,116) had an increased risk of developing cataracts (HR 2.21; 95% CI 2.12-2.31). Of the patients who received a cataract diagnosis, NTNP exposure was associated with higher risk of receiving cataract surgery (HR 2.93; 95% CI 2.77-3.09) within 5 years.
CONCLUSION: NTNP usage may be associated with cataract development. Given their widespread use in recent years, they may pose considerable public health risks, and it would be prudent to further investigate their relationship with cataracts.