Acceleration of skin tumorigenesis in mice by submandibular and sublingual gland excision.

Sialoadenectomized CD-1 male mice reached 50% incidence earlier and developed new tumors faster than either sham operated or control mice. Surgically treated mice regained normal body weight within two weeks, at which time skin tumors were induced by benzo[a]pyrene initiation and 12-O-tetradecanoylphorbol-13-acetate promotion.