The Journal of clinical endocrinology and metabolism · 2015
Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women.
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Barja-Fernández Silvia, Folgueira Cintia, Seoane Luisa M, Casanueva Felipe F, Dieguez Carlos, Castelao Cecilia, Agüera Zaida, Baños Rosa, Botella Cristina, de la Torre Rafael, Fernández-García Jose C, Fernández-Real Jose M, Frühbeck Gema, Gómez-Ambrosi Javier, Jiménez-Murcia Susana, Tinahones Francisco J, Estivill Xavier, Fernández-Aranda Fernando, Nogueiras Ruben
Аннотация
CONTEXT: Betatrophin is produced primarily by liver and adipose tissue and has been recently reported as a novel hormone promoting β-cell proliferation and β-cell mass and improving glucose tolerance.
OBJECTIVE: Because it is markedly regulated by nutritional status, we hypothesized that circulating betatrophin levels might be affected by pathophysiological conditions altering body weight.
SETTING AND PATIENTS: We analyzed circulating betatrophin levels in 149 female patients, including 99 with extreme body mass index (30 anorexia nervosa, 24 obese, 45 morbid obese, and 50 healthy eating/weight controls).
OUTCOME MEASUREMENTS: Serum betatrophin levels and its correlations with different anthropometric and biochemical parameters were measured.
RESULTS: Plasma betatrophin levels were significantly elevated in anorexic patients, whereas its levels were reduced in morbidly obese women when compared with normal-weight women. Plasma betatrophin correlated negatively with weight, body mass index, fat percentage, glucose, insulin, and homeostatic model assessment index and positively correlated with high-density lipoprotein.
CONCLUSIONS: These results suggest that metabolic status is an important regulator of circulating betatrophin levels.
OBJECTIVE: Because it is markedly regulated by nutritional status, we hypothesized that circulating betatrophin levels might be affected by pathophysiological conditions altering body weight.
SETTING AND PATIENTS: We analyzed circulating betatrophin levels in 149 female patients, including 99 with extreme body mass index (30 anorexia nervosa, 24 obese, 45 morbid obese, and 50 healthy eating/weight controls).
OUTCOME MEASUREMENTS: Serum betatrophin levels and its correlations with different anthropometric and biochemical parameters were measured.
RESULTS: Plasma betatrophin levels were significantly elevated in anorexic patients, whereas its levels were reduced in morbidly obese women when compared with normal-weight women. Plasma betatrophin correlated negatively with weight, body mass index, fat percentage, glucose, insulin, and homeostatic model assessment index and positively correlated with high-density lipoprotein.
CONCLUSIONS: These results suggest that metabolic status is an important regulator of circulating betatrophin levels.