Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium.
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Collatuzzo Giulia, Negri Eva, Pelucchi Claudio, Bonzi Rossella, Turati Federica, Rabkin Charles S, Liao Linda M, Sinha Rashmi, Palli Domenico, Ferraroni Monica, López-Carrillo Lizbeth, Lunet Nuno, Morais Samantha, Albanes Demetrius, Weinstein Stephanie J, Parisi Dominick, Zaridze David, Maximovitch Dmitry, Dierssen-Sotos Trinidad, Jiménez-Moleón José Juan, Vioque Jesus, Garcia de la Hera Manoli, Curado Maria Paula, Dias-Neto Emmanuel, Hernández-Ramírez Raúl Ulises, López-Cervantes Malaquias, Ward Mary H, Tsugane Shoichiro, Hidaka Akihisa, Lagiou Areti, Lagiou Pagona, Zhang Zuo-Feng, Trichopoulou Antonia, Karakatsani Anna, Camargo Maria Constanza, La Vecchia Carlo, Boffetta Paolo
Аннотация
METHODS: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted.
RESULTS: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94-1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88-0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85-0.99) and 0.78 (95% CI = 0.73-0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91-1.02) for cardia, 1.03 (95% CI = 1.00-1.07) for non-cardia, 1.12 (95% CI = 1.07-1.19) for diffuse and 1.02 (95% CI = 0.97-1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women.
CONCLUSIONS: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.