Effect of the C-terminal tetrapeptide amide of gastrin (CCK-4) and pancreatic polypeptide on gastrointestinal electrical activity in the conscious miniature pig.

The effect of IV infusion of CCK-4, 33.2 and 332 pM/kg/min, and pancreatic polypeptide (PP), 4.8 and 48 pM/kg/min, on gastrointestinal electrical activity was studied in conscious miniature pigs with electrodes implanted in the wall of the antrum pylori and small intestine. In the antrum pylori infusion of the higher dose of both peptides provoked an increase in frequency of the basic electrical rhythm together with a decrease in frequency of spike bursts. In the studied dose range CCK-4 and PP were without influence on small intestinal electrical activity.