Natural product research · 2022
Polymeric film containing pomegranate peel extract as a promising tool for the treatment of candidiasis.
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de Paula Geanne Aparecida, Costa Nubya Nascimento, da Silva Thais Martins, Bastos Kamila Arêas, Ignacchiti Mariana Drummond Costa, Severi Juliana Aparecida, Oréfice Rodrigo Lambert, Carreira Lílian Gasparelli, Villanova Janaina Cecília Oliveira, Resende Juliana Alves
Аннотация
Polymeric films containing pomegranate peel extract (PPE) can act as a drug-delivery platform for topical treatment of candidiasis. The composition, mechanical resistance, and in vitro antifungal activity of a polymeric film containing PPE at 1.25 mg.mL-1 were investigated. Films were prepared using a solvent casting technique. The incorporation of PPE in the polymeric matrix gave rise to homogeneous, smooth, shiny, and yellowish-brown films. FTIR spectra of the film containing PPE showed differences without compromising the stability of the extract and the matrix. SEM analysis showed the existence of interruptions in the continuity of the films with extract, which promoted a reduction in the mechanical parameters without significantly changing the tensile strength and elongation at break. Films showed adequate mechanical properties and antifungal activity against Candida albicans, C. glabrata, C. krusei and C. tropicalis.