Journal of hypertension · 2026
Intensive versus routine blood pressure control in patients with type 2 diabetes: A Meta-analysis and Trial sequential analysis.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
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Ikram Jibran, Ali Aizaz, Huma Sundus, Shah Syed Wajihullah, Ahmad Muhammad, Khan Muhammad Momin, Khan Abuzar, Khan Afra, Pirih Fnu, Khattak Asad Iqbal, Zaman Bushra, Ali Muhammad Abdullah, Sawaira Fnu, Haider Farooq, Mushtaq Ali, Zahid Ayesha, Mankani Muhammad Hasnain, Sessler Daniel I
Аннотация
Optimal blood pressure (BP) targets for type 2 diabetes remain controversial. Although intensive BP control reduces cardiovascular risk in the general population, its net benefit in diabetes is uncertain. We conducted a systematic review and meta-analysis of randomized controlled trials comparing intensive BP control (target < 130/80 mmHg or achieved systolic <130 mmHg) with routine control in adults with type 2 diabetes. Databases (PubMed, Embase, Cochrane CENTRAL) were searched through November 2024; two reviewers independently extracted data and assessed bias. Random-effects meta-analysis estimated pooled relative risks (RRs) with 95% confidence intervals (CIs), and trial sequential analysis (TSA) assessed robustness. Eleven trials comprising 24,308 participants met inclusion criteria. Intensive BP control reduced stroke (RR: 0.64; 95% CI: 0.51-0.81) and major cardiovascular events (RR: 0.86; 95% CI: 0.72-1.03) with no significant differences in mortality or heart-failure hospitalization. TSA confirmed firm evidence for stroke reduction, mortality and heart failure results remained inconclusive.