Experiments on lymphocyte-mediated cellular immunity in murine histoplasmosis.

Peritoneal exudate cells from immunized mice inhibit the intracellular growth of Histoplasma capsulatum. The lymphocyte is the mediator cell of this phenomenon. Lymphocytes from immunized animals are highly activated cells. Supernatants from cultures of immune lymphocytes or from cultures of mitogen-stimulated lymphocytes did not arm macrophages from normal animals to inhibit the intracellular growth of H. capsulatum.