Neuroepidemiology · 2024
Multiple Aneurysms: Insight through the Mirrors.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Constant Dit Beaufils Pacôme, Karakachoff Matilde, Thouant Pierre, Gourraud Pierre-Antoine, Zhu François, Lindgren Antti, Bourcier Romain
Аннотация
INTRODUCTION: Mirror intracranial aneurysms (MIAs) are intracranial aneurysms (IAs) located bilaterally and symmetrically on either side of the circle of Willis. This study explored the characteristics of MIAs and examined their prevalence at various intracranial locations in a large international population with multiple IAs, aimed at shedding light on the concept of MIA.
METHOD: Data were collected from cohorts of patients in France and Finland with ≥2 definite saccular arterial dilatations at intracranial vessel bifurcations. Patients were classified as "MIA patients" if they had bilateral, symmetrically located IAs and further classified as having a pure phenotype (i.e., no other IAs present) or a mixed phenotype if non-mirror additional IAs were present. Statistical analysis used logistic regression models to assess the association of IA location with MIA status and conditional probabilities were calculated for paired locations.
RESULTS: In a population of 2,124 patients with 5,459 IAs, 754 patients (33.5%) with a mean age 55.5 (SD 11.3) years had 798 MIAs. MIA patients were predominantly female (541; 72%). We found no relevant differences in clinical characteristics between MIA and non-MIA patients. Middle cerebral artery (MCA) location was the only variable independently associated with MIA status (OR 1.36 [95% CI 1.07%-1.71%], p = 0.0101).
CONCLUSION: MIAs on MCA is a distinct condition among patients with multiple IAs, indicating a potential focal vulnerability related to a predisposing anatomical factor. Particular care is therefore needed during IA screening and follow-up to identify and manage MIAs.
METHOD: Data were collected from cohorts of patients in France and Finland with ≥2 definite saccular arterial dilatations at intracranial vessel bifurcations. Patients were classified as "MIA patients" if they had bilateral, symmetrically located IAs and further classified as having a pure phenotype (i.e., no other IAs present) or a mixed phenotype if non-mirror additional IAs were present. Statistical analysis used logistic regression models to assess the association of IA location with MIA status and conditional probabilities were calculated for paired locations.
RESULTS: In a population of 2,124 patients with 5,459 IAs, 754 patients (33.5%) with a mean age 55.5 (SD 11.3) years had 798 MIAs. MIA patients were predominantly female (541; 72%). We found no relevant differences in clinical characteristics between MIA and non-MIA patients. Middle cerebral artery (MCA) location was the only variable independently associated with MIA status (OR 1.36 [95% CI 1.07%-1.71%], p = 0.0101).
CONCLUSION: MIAs on MCA is a distinct condition among patients with multiple IAs, indicating a potential focal vulnerability related to a predisposing anatomical factor. Particular care is therefore needed during IA screening and follow-up to identify and manage MIAs.