Journal of fungi (Basel, Switzerland) · 2019
Antifungal Resistance in Clinical Isolates of Aspergillus spp.: When Local Epidemiology Breaks the Norm.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Romero Mercedes, Messina Fernando, Marin Emmanuel, Arechavala Alicia, Depardo Roxana, Walker Laura, Negroni Ricardo, Santiso Gabriela
Аннотация
Aspergillosis is a set of very frequent and widely distributed opportunistic diseases. Azoles are the first choice for most clinical forms. However, the distribution of azole-resistant strains is not well known around the world, especially in developing countries. The aim of our study was to determine the proportion of non-wild type strains among the clinical isolates of Aspergillus spp. To this end, the minimum inhibitory concentration of three azoles and amphotericin B (used occasionally in severe forms) was studied by broth microdilution. Unexpectedly, it was found that 8.1% of the isolates studied have a diminished susceptibility to itraconazole. This value turned out to be similar to the highest azole resistance rate reported in different countries across the world.