Zhen ci yan jiu = Acupuncture research · 2014
[Effects of electroacupuncture stimulation of "Shenmen"(HT 7)-"Taiyuan" (LU 9) on auditory sensory gating P 50 in acute myocardial ischemia rabbits].
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Yu Qing, Hu Ling, Wu Zi-jian, Cai Rong-lin, Wang Jie, Wang Chun-hua, Liu Lei
Аннотация
OBJECTIVE: To observe the effect of electroacupuncture (EA) stimulation of "Shenmen" (HT 7) and "Taiyuan"(LU 9) on P50 event-related potentials in rabbits with acute myocardial ischemia (AMI), so as to evaluate the specificity of function of different acupoints.
METHODS: Chinchilla rabbits were randomized into normal control, model, Shenmen (HT 7) and Taiyuan (LU 9) groups (n = 10/group). AMI model was established by temporary occlusion of the descending anterior branch of the left coronary artery. EA (1 mA, 2 Hz) was applied to bilateral HT 7 and LU 9 for 15 min. The anesthetized-rabbit's heart rate (HR) was recorded by using a BIOPAC system and the latency and amplitude of auditory sensory gating potential P 50 were measured by paired clicks auditory conditioning (S 1-P 50)/testing (S 2-P 50) stimulus paradigm using a Neuroscan workstation.
RESULTS: In comparison with the normal control group, the HR was significantly decreased in the model group and significantly increased in the HT 7 group than in the model group (P<0. 01). Compared to the normal control group, the amplitude of S 2-P 50 and ratio of amplitude of S 2-P 50/S 1-P 50 were significantly increased in the model group (P<0. 01), and remarkably down-regulated in the HT 7 group than in the model group (P<0. 01),suggesting an inhibitory effect of EA stimulation of HT 7 on cerebral cortical auditory gating potential in AMI rabbits. No significant changes were found in the latencies of S 1-P 50, S2-P 50 potentials in both HT 7 and LU 9 groups and in the HR, amplitude of S 2-P 50 and ratio of amplitude of S 2-P 50/S 1-P 50 in the LU 9 group (P>0. 05).
CONCLUSION: EA stimulation of HT 7 can correct AMI induced decrease of HR and increase of P 50 potential amplitude in AMI rabbits, while EA of LU 9 has no this effect, suggesting a relatively specific effect of different acupoints on cortical sensory gating.
METHODS: Chinchilla rabbits were randomized into normal control, model, Shenmen (HT 7) and Taiyuan (LU 9) groups (n = 10/group). AMI model was established by temporary occlusion of the descending anterior branch of the left coronary artery. EA (1 mA, 2 Hz) was applied to bilateral HT 7 and LU 9 for 15 min. The anesthetized-rabbit's heart rate (HR) was recorded by using a BIOPAC system and the latency and amplitude of auditory sensory gating potential P 50 were measured by paired clicks auditory conditioning (S 1-P 50)/testing (S 2-P 50) stimulus paradigm using a Neuroscan workstation.
RESULTS: In comparison with the normal control group, the HR was significantly decreased in the model group and significantly increased in the HT 7 group than in the model group (P<0. 01). Compared to the normal control group, the amplitude of S 2-P 50 and ratio of amplitude of S 2-P 50/S 1-P 50 were significantly increased in the model group (P<0. 01), and remarkably down-regulated in the HT 7 group than in the model group (P<0. 01),suggesting an inhibitory effect of EA stimulation of HT 7 on cerebral cortical auditory gating potential in AMI rabbits. No significant changes were found in the latencies of S 1-P 50, S2-P 50 potentials in both HT 7 and LU 9 groups and in the HR, amplitude of S 2-P 50 and ratio of amplitude of S 2-P 50/S 1-P 50 in the LU 9 group (P>0. 05).
CONCLUSION: EA stimulation of HT 7 can correct AMI induced decrease of HR and increase of P 50 potential amplitude in AMI rabbits, while EA of LU 9 has no this effect, suggesting a relatively specific effect of different acupoints on cortical sensory gating.