Role of hyaluronic acid gel as an adjunct to temporalis fascia graft tympanoplasty in total tympanic membrane perforation: A randomized controlled trial.

AIM: This study aimed to evaluate the efficacy of hyaluronic acid gel as an adjunct to temporalis fascia graft tympanoplasty in total tympanic membrane perforation.

METHODS

A prospective single blinded randomized controlled trial carried out among 60 patients with total tympanic membrane perforation randomized into 2 groups A&B each comprised of 30 patients. Patients in group A underwent underlay tympanoplasty using temporalis fascia graft through postauricular approach with the utilization of hyaluronic acid gel as an adjunct to temporalis fascia graft. Patients in group B underwent classic underlay tympanoplasty using temporalis fascia graft through postauricular approach. Both groups were compared as regards graft success rate as well as hearing outcome.

RESULTS

The difference in the graft success rate between group A (93.33%) and group B (80%) was statistically significant (P value = .04). Preoperative air conduction (AC) threshold and air bong gap (ABG) showed no statistically significant differences between both groups. Postoperative AC thresholds for groups A and B were 23.55 ± 3.69 dB and 26.40 ± 5.26 dB respectively with statistically significant difference (P value = .04). Postoperative ABG for groups A and B were 8.90 ± 4.07 dB and 12.00 ± 5.41 dB respectively and this difference was also statistically significant (P value = .03).

CONCLUSION

Utilization of hyaluronic acid gel as an adjunct to temporalis fascia graft tympanoplasty can improve the graft success rate.