Scientific reports · 2023
Association between reduced left ventricular ejection fraction and peritoneal dialysis related peritonitis: a single center retrospective cohort study in Japan.
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Yamaguchi Makoto, Obayashi Takaaki, Kobayashi Naoto, Izumi Naoki, Nagai Masaaki, Nobata Hironobu, Asai Akimasa, Kamiya Keisuke, Sugiyama Hirokazu, Kinashi Hiroshi, Banno Shogo, Ando Masahiko, Imaizumi Takahiro, Kubo Yoko, Katsuno Takayuki, Ishimoto Takuji, Ito Yasuhiko
Аннотация
We present a single-center retrospective analysis of 228 Japanese patients with peritoneal dialysis, in which we examined whether reduced left ventricular ejection fraction (LVEF) is a risk factor for peritonitis development. Time-dependent multivariable-adjusted Cox proportional hazards models revealed that reduced LVEF (LVEF < 50% vs. preserved LVEF ≥ 50%, hazard ratio (HR) 2.10; 95% confidence interval (CI) 1.16-3.82) was associated with peritonitis. Qualitatively, similar associations with reduced LVEF (< 50%) were observed for enteric peritonitis (adjusted HR 7.68; 95% CI 2.51-23.5) but not for non-enteric peritonitis (adjusted HR 1.15; 95% CI 0.54-2.44). Reduced LVEF is associated with a significantly higher risk of subsequent peritonitis, particularly enteric peritonitis. These results indicate that patients with reduced LVEF may be at risk of enteric peritonitis from bowel sources caused by intestinal involvement due to cardiac dysfunction.