Ghana medical journal · 2023
Plasma concentration of fucosyltransferase 7 is not associated with the number of clinically overt vaso-occlusive events in sickle cell disease.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Okpala Iheanyi E, Eze Onyinye E, Ezekekwu Chinedu A, Nnakenyi Ifeyinwa D, Ilechukwu Gladys U, Akpa Chinedu O, Nwani Emmanuel I, Maduka Collins J, Anigbogu Ikechukwu O, Muoghalu Ebele D, Ugwu Ngozi I, Ajuba Ifeoma C, Aneke John C, Okoye Helen C, Nonyelu Charles C, Duru Augustine N
Аннотация
OBJECTIVE: To determine if the number of vaso-occlusive events in SCD relates to plasma concentration of fucosyltransferase 7 (FUT7), which catalyses the synthesis of selectin ligands.
DESIGN: A prospective, analytical study.
SETTING: Haematology and Chemical Pathology Departments of tertiary healthcare centres.
PARTICIPANTS: Steady state HbSS individuals aged 13-45 years, 20 had 3 or more vaso-occlusive crises that required hospital admission in the previous year (with or without complications of SCD); 17 other HbSS persons had 0-1 vaso-occlusive crisis that required hospital admission in the previous year and no disease complications.
INTERVENTION: Steady-state plasma concentrations of FUT7 measured by ELISA were compared between SCD patients who had one vaso-occlusive crisis requiring hospital treatment in the previous year but no disease complications and those who had >3 crises with or without complications.
MAIN OUTCOME MEASURES: Plasma level of FUT7and the number of vaso-occlusive events in each HbSS patient.
RESULTS: Mean + standard deviation plasma concentration of FUT7 was 8.6 + 2.7 ng/ml in patients with >3 vasoocclusive crises in the previous year and 7.3 + 1.7 ng/ml in those with 0-1 crisis and no complications; independent sample t-test, p > 0.05, not significantly different.
CONCLUSION: Plasma concentration of fucosyltransferase7 is not associated with the number of vaso-occlusive events in sickle cell disease.
FUNDING: None declared.
DESIGN: A prospective, analytical study.
SETTING: Haematology and Chemical Pathology Departments of tertiary healthcare centres.
PARTICIPANTS: Steady state HbSS individuals aged 13-45 years, 20 had 3 or more vaso-occlusive crises that required hospital admission in the previous year (with or without complications of SCD); 17 other HbSS persons had 0-1 vaso-occlusive crisis that required hospital admission in the previous year and no disease complications.
INTERVENTION: Steady-state plasma concentrations of FUT7 measured by ELISA were compared between SCD patients who had one vaso-occlusive crisis requiring hospital treatment in the previous year but no disease complications and those who had >3 crises with or without complications.
MAIN OUTCOME MEASURES: Plasma level of FUT7and the number of vaso-occlusive events in each HbSS patient.
RESULTS: Mean + standard deviation plasma concentration of FUT7 was 8.6 + 2.7 ng/ml in patients with >3 vasoocclusive crises in the previous year and 7.3 + 1.7 ng/ml in those with 0-1 crisis and no complications; independent sample t-test, p > 0.05, not significantly different.
CONCLUSION: Plasma concentration of fucosyltransferase7 is not associated with the number of vaso-occlusive events in sickle cell disease.
FUNDING: None declared.