Affinity-purified Plasmodium tubulin provides a key reagent for antimalarial drug development.

Hirst et al. used a TOG-domain-based affinity-purification approach to reconstitute and define the in vitro dynamics of blood-stage Plasmodium falciparum αβ-tubulin. This provides a key reagent for defining parasite microtubule (MT) dynamics and for evaluating the efficacy of anti-MT drugs throughout the complex parasite life cycle.