Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists · 2016
Early improvement predicts 8-week treatment outcome in patients with generalized anxiety disorder treated with escitalopram or venlafaxine.
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Qian Mincai, Shen Zhongxia, Lin Min, Guan Tiefeng, Yang Jianhong, Li Liang, Shen Xinhua, Yuan Yonggui
Аннотация
INTRODUCTION: To investigate whether early improvement can predict 8-week treatment outcome in generalized anxiety disorder (GAD) patients.
METHODS: For 8 weeks, 226 GAD patients were randomly treated with escitalopram or venlafaxine. Early improvement was defined as a ≧20% reduction from baseline in Hamilton anxiety rating scale at week 1 or 2. The positive and negative predictive values were calculated.
RESULTS: The positive and negative predictive values of early improvement in escitalopram or venlafaxine group at week 1 were (85.19%, 67.53%) vs (84.62%, 65.33%) DISCUSSION: The early improvement achieved within the first week treatment can predict a good 8-week treatment outcome in GAD patients.
METHODS: For 8 weeks, 226 GAD patients were randomly treated with escitalopram or venlafaxine. Early improvement was defined as a ≧20% reduction from baseline in Hamilton anxiety rating scale at week 1 or 2. The positive and negative predictive values were calculated.
RESULTS: The positive and negative predictive values of early improvement in escitalopram or venlafaxine group at week 1 were (85.19%, 67.53%) vs (84.62%, 65.33%) DISCUSSION: The early improvement achieved within the first week treatment can predict a good 8-week treatment outcome in GAD patients.