Gan to kagaku ryoho. Cancer & chemotherapy · 2021
[A Case of SM Carcinoma of the Sigmoid Colon with Distant Metastasis in the Early Stage after Endoscopic MucosalResection].
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Takashima Junpei, Kobayashi Hirotoshi, Suzuki Yuta, Koizumi Ayaka, Akasaki Takayuki, Shigehara Fumi, Tsukamoto Mitsuo, Yamasaki Kenji, Sugimoto Hitoshi, Fujimoto Daisuke, Miura Fumihiko, Taniguchi Keizo, Matsutani Noriyuki, Takahashi Mikiko
Аннотация
INTRODUCTION: We report a case of submucosal(SM)adenocarcinoma of the sigmoid colon which developed distant metastasis 3 months after endoscopic mucosal resection(EMR).
CASE: 54-year-old, male. Colonoscopy, which was performed due to positive fecal occult blood test, revealed 18 mm Isp sigmoid polyp. EMR was performed with en bloc resection. Pathological examination revealed adenocarcinoma(tub>por>sig), pT1b, Ly1c, V1a, pHM0, and pVM1. Therefore, laparoscopic sigmoidectomy(D2 dissection)was performed. Postoperative pathological examination revealed pT1b, pN2b(10/11), PN1b, pPM0, pDM0, pStage Ⅲb. Distant nodal involvement were found on computed tomography 3 months after EMR, although systemic chemotherapy(mFOLFOX6 plus panitumumab 18 courses and FOLFIRI plus bevacizumab 4 courses)was performed, the patient died of liver failure caused by liver metastasis 21 months after EMR.
CONCLUSION: We present a case of T1 sigmoid adenocarcinoma which developed distant metastasis 3 months after EMR with literature review.
CASE: 54-year-old, male. Colonoscopy, which was performed due to positive fecal occult blood test, revealed 18 mm Isp sigmoid polyp. EMR was performed with en bloc resection. Pathological examination revealed adenocarcinoma(tub>por>sig), pT1b, Ly1c, V1a, pHM0, and pVM1. Therefore, laparoscopic sigmoidectomy(D2 dissection)was performed. Postoperative pathological examination revealed pT1b, pN2b(10/11), PN1b, pPM0, pDM0, pStage Ⅲb. Distant nodal involvement were found on computed tomography 3 months after EMR, although systemic chemotherapy(mFOLFOX6 plus panitumumab 18 courses and FOLFIRI plus bevacizumab 4 courses)was performed, the patient died of liver failure caused by liver metastasis 21 months after EMR.
CONCLUSION: We present a case of T1 sigmoid adenocarcinoma which developed distant metastasis 3 months after EMR with literature review.