Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2013
Angiotensinogen promoter and angiotensinogen II receptor type 1 gene polymorphisms and incidence of ischemic stroke and neurologic phenotype in Fabry disease.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Altarescu Gheona, Haim Shimon, Elstein Deborah
Аннотация
CONTEXT: Stroke and/or white matter lesions (WMLs) are significant in Fabry disease. Polymorphisms of angiotensinogen (AGT), AGT Promoter and angiotensinogen II receptor type 1 (AGTR1) are correlated with WMLs.
OBJECTIVES: We compared AGT. AGT Promoter and AGTR1 genotypes to stroke incidence, Fabry-specific [Mainz Severity Score Index (MSSI)] severity score, and neurologic sub-score (n-MSSI).
METHODS: Sixty-three Fabry patients and 49 matched controls plus historic controls were genotyped. Institutional Review Board approval was received. Results. C and/or CC alleles of AGT Promoter and AGTR1 were significantly correlated with stroke and n-MSSI.
DISCUSSION/CONCLUSION: Findings are suggestive of role of AGT Promoter and AGTR1 genotypes in Fabry phenotypes.
OBJECTIVES: We compared AGT. AGT Promoter and AGTR1 genotypes to stroke incidence, Fabry-specific [Mainz Severity Score Index (MSSI)] severity score, and neurologic sub-score (n-MSSI).
METHODS: Sixty-three Fabry patients and 49 matched controls plus historic controls were genotyped. Institutional Review Board approval was received. Results. C and/or CC alleles of AGT Promoter and AGTR1 were significantly correlated with stroke and n-MSSI.
DISCUSSION/CONCLUSION: Findings are suggestive of role of AGT Promoter and AGTR1 genotypes in Fabry phenotypes.
Предметные рубрики MeSH
AdolescentAdultAngiotensinogenBrain IschemiaCase-Control StudiesFabry DiseaseFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHumansIncidenceMaleMiddle AgedPhenotypePolymorphism, GeneticPrevalencePromoter Regions, GeneticReceptor, Angiotensin, Type 1Severity of Illness IndexYoung Adult