Loading and release of amphotericin-B from biodegradable poly(lactic-co-glycolic acid) nanoparticles.

Amphotericin B (AmB)-loaded poly(lactic-co-glycolic acid, PLGA) nanoparticles (NP) were prepared by solvent displacement. NP of size 160.7 +/- 10.45 nm, with a polydispersity index of 0.093 +/- 0.012 and a zeta-potential of -15.5 +/- 7.2 mV had satisfactory drug entrapment efficiency (42.5 +/- 6.41%). Biphasic drug release characterized by an initial burst followed by subsequent sustained release was observed. Applicability against visceral leishmaniasis and cancer is under investigation.