European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2014
Predictors of survival after resection of children with hepatoblastoma: A single Asian center experience.
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Qiao G-L, Li L, Cheng W, Ge J, Zhang Z, Wei Y
Аннотация
AIM: The aim of this study is to investigate and identify the predictors associated with the prognosis of patients with hepatoblastoma (HB).
METHODS: We retrospectively reviewed 112 children with HB (58 female, 54 male) managed in our institution between May 1st, 2001 and January 30th, 2012. Prognostic factors were evaluated using Kaplan-Meier curves and Cox proportional hazards models.
RESULTS: For the entire cohort of 112 patients, the overall median survival was 83.5 months, and the 5-year EFS and OS rates were 57.1% and 63.4%, AFP<100 or >1000 (ng/ml)(HR:2.454, P = 0.013), multifocality (HR:2.852, P = 0.012), vascular invasion (HR:2.272, P = 0.026), metastases (HR:2.654,P = 0.005) and PRETEXT stage (HR:2.817, P = 0.005) were associated with an adverse prognosis in the univariate and multivariable adjusted analysis. Based on these findings, a prognostic scoring system was developed that allotted one point each for these factors. Patients with HB could be stratified into 3 distinct prognostic groups (median and 5-year EFS, respectively): 0 points (105.1 months, 94.1%), 1-2 point (85.8 months, 60.2%), and 3-4 points (31.8 months, 13.5%) (P < 0.001).
CONCLUSIONS: We have confirmed the HB prognostic factors associated with survival in the Asian population and established a simple prognostic scoring system.
METHODS: We retrospectively reviewed 112 children with HB (58 female, 54 male) managed in our institution between May 1st, 2001 and January 30th, 2012. Prognostic factors were evaluated using Kaplan-Meier curves and Cox proportional hazards models.
RESULTS: For the entire cohort of 112 patients, the overall median survival was 83.5 months, and the 5-year EFS and OS rates were 57.1% and 63.4%, AFP<100 or >1000 (ng/ml)(HR:2.454, P = 0.013), multifocality (HR:2.852, P = 0.012), vascular invasion (HR:2.272, P = 0.026), metastases (HR:2.654,P = 0.005) and PRETEXT stage (HR:2.817, P = 0.005) were associated with an adverse prognosis in the univariate and multivariable adjusted analysis. Based on these findings, a prognostic scoring system was developed that allotted one point each for these factors. Patients with HB could be stratified into 3 distinct prognostic groups (median and 5-year EFS, respectively): 0 points (105.1 months, 94.1%), 1-2 point (85.8 months, 60.2%), and 3-4 points (31.8 months, 13.5%) (P < 0.001).
CONCLUSIONS: We have confirmed the HB prognostic factors associated with survival in the Asian population and established a simple prognostic scoring system.
Предметные рубрики MeSH
Biomarkers, TumorCA-19-9 AntigenCarcinoembryonic AntigenChinaCohort StudiesFemaleHepatoblastomaHumansInfantKaplan-Meier EstimateLiver NeoplasmsMaleMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingNeoplasms, Multiple PrimaryPrognosisProportional Hazards ModelsRetrospective StudiesRisk FactorsTumor Burdenalpha-Fetoproteins