BMJ (Clinical research ed.) · 1994
Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study.
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Kuusisto J, Koivisto K, Kervinen K, Mykkänen L, Helkala E L, Vanhanen M, Hänninen T, Pyörälä K, Kesäniemi Y A, Riekkinen P
Аннотация
OBJECTIVE: To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample.
DESIGN: Cross sectional population based study.
SUBJECTS: 980 people aged 69 to 78 (349 men, 631 women).
SETTING: Population of Kuopio, eastern Finland.
MAIN OUTCOME MEASURES: Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation.
RESULTS: 46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 subjects without dementia (P < 0.0001). The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E.
CONCLUSIONS: Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population.
DESIGN: Cross sectional population based study.
SUBJECTS: 980 people aged 69 to 78 (349 men, 631 women).
SETTING: Population of Kuopio, eastern Finland.
MAIN OUTCOME MEASURES: Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation.
RESULTS: 46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 subjects without dementia (P < 0.0001). The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E.
CONCLUSIONS: Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population.